基本信息:
- 专利标题： 金属硫族化合物多功能纳米探针的制备方法及其应用
- 专利标题（英）：Preparation method and application of metal sulfur-group compound multifunctional nano probe
- 申请号：CN201610213490.2 申请日：2016-04-08
- 公开(公告)号：CN105754584A 公开(公告)日：2016-07-13
- 发明人： 李桢 , 张少华
- 申请人： 苏州大学
- 申请人地址： 江苏省苏州市工业园区仁爱路199号
- 专利权人： 苏州大学
- 当前专利权人： 苏州大学
- 当前专利权人地址： 江苏省苏州市工业园区仁爱路199号
- 代理机构： 苏州市中南伟业知识产权代理事务所
- 代理人： 李阳
- 主分类号： C09K11/02
- IPC分类号： C09K11/02 ; C09K11/88 ; B82Y30/00 ; B82Y40/00 ; A61K41/00 ; A61K51/06
The invention belongs to the field of material chemistry and biological medicine, and in particular relates to a preparation method and application of a metal sulfur-group compound multifunctional nano probe. The preparation method comprises the following steps: in the presence of a water-soluble sulfhydryl compound or a biocompatible molecule, enabling low-valence sulfur group anions to have stirred mixing reaction with metal cations in an aqueous solution; and then, centrifuging, carrying out ultrafiltration, modifying, dialyzing and purifying to obtain water-soluble metal sulfur-group compound nanoparticles which can be used for photoacoustic imaging, CT imaging, nuclear medical imaging and photothermal therapy. The preparation method is gentle, cheap, quick and efficient; and the obtained nano microparticles are small in size, can circulate for a relatively long time in vivo, and can be gathered in tumors by enhancing permeation and retention effects.
公开/授权文献:
- CN105754584B 金属硫族化合物多功能纳米探针的制备方法及其应用 公开/授权日：2018-08-24