基本信息:
- 专利标题： 一种对称取代吡咯化合物的合成方法
- 专利标题（英）：Synthetic method of symmetrically-substituted pyrrole compound
- 申请号：CN201610064159.9 申请日：2016-01-29
- 公开(公告)号：CN105732455A 公开(公告)日：2016-07-06
- 发明人： 程天行 , 陈久喜 , 戚林军 , 于书玲 , 胡堃
- 申请人： 温州大学
- 申请人地址： 浙江省温州市瓯海区东方南路38号温州市国家大学科技园孵化器
- 专利权人： 温州大学
- 当前专利权人： 温州大学
- 当前专利权人地址： 浙江省温州市瓯海区东方南路38号温州市国家大学科技园孵化器
- 代理机构： 北京世誉鑫诚专利代理事务所
- 代理人： 郭官厚
- 主分类号： C07D207/323
- IPC分类号： C07D207/323
The invention relates to a synthetic method of a symmetrically-substituted pyrrole compound as shown in the formula (III). The method comprises the following steps: in a solvent and in the existence of a catalyst, a ligand, an acid compound and an ammonium source compound, performing the reaction of a compound as shown in the formula (I) and a compound as shown in the formula (II), and performing post-treatment after the reaction is ended, thereby obtaining a compound as shown in the formula (III) in the specification, wherein R is H, halogen, alkyl of C1 to C6 or alkoxy of C1 to C6; and X is an alkali metal element. According to the method, by virtue of the comprehensive selection and synergism of the specific catalyst, the ligand, the acid compound, the ammonium source compound and the solvent, the symmetrically-substituted pyrrole compound is obtained in high yield, and the application prospect and the industrialized production potential are good in the field of organic chemical synthesis.
公开/授权文献:
- CN105732455B 一种对称取代吡咯化合物的合成方法 公开/授权日：2018-03-06
IPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07D | 杂环化合物 |
| ------C07D207/00 | 杂环化合物，含五元环，不与其他环稠合，带1个氮原子作为惟一的环杂原 |
| --------C07D207/02 | .只有氧或碳原子直接连在环氮原子上 |
| ----------C07D207/04 | ..环原子间或环原子与非环原子间无双键 |
| ------------C07D207/32 | ...只有氢原子，烃基或取代的烃基，直接连在碳原子上 |
| --------------C07D207/323 | ....只有氢原子，或只含氢和碳原子的基，直接连在环氮原子上 |