The invention discloses a mobile express delivery box. The mobile express delivery box comprises a shell and a top cover, one side of the shell is provided with a door, a rotary bottom plate is arranged in the shell, eight small article containers are arranged above four large article containers which are arranged on the rotary bottom plate, the rotary bottom plate is connected with a motor through a transmission system, and the small article containers are connected with the large article containers through planetary gear reducers. The four large article containers are uniformly and circumferentially distributed, and when an input shaft rotates by one circle and the rotary bottom plate rotates by 90 degrees, one of the large article containers faces the door; the eight small article containers are uniformly and circumferentially distributed, and when the large article containers rotate by 90 degrees and the small article containers rotate by 45 degrees, one of the small article containers face the door. A slide groove and a lock are arranged between the shell and the door, and the door is provided with small doors which are provided with password unlocking devices respectively. The mobile express delivery box is simple in structure, delivered articles can be fetched conveniently, clients are allowed to freely arrange time for fetching the delivered articles, occupancy of working and resting time is avoided, and manpower resources are greatly saved.