
基本信息:
- 专利标题: 麝香草酚的制备方法
- 专利标题(英):Preparation method of thymol crystals
- 申请号:CN201610040090.6 申请日:2016-01-21
- 公开(公告)号:CN105693471A 公开(公告)日:2016-06-22
- 发明人: 王学亮
- 申请人: 上海延安药业(湖北)有限公司
- 申请人地址: 湖北省天门市天岳大道特1号
- 专利权人: 上海延安药业(湖北)有限公司
- 当前专利权人: 上海延安药业(湖北)有限公司
- 当前专利权人地址: 湖北省天门市天岳大道特1号
- 代理机构: 上海汉声知识产权代理有限公司
- 代理人: 郭国中
- 主分类号: C07C37/06
- IPC分类号: C07C37/06 ; C07C39/06 ; B01J23/755 ; B01J23/92
The invention provides a preparation method of thymol crystals, which comprises the following steps: after mixing eucalyptus oil and silica gel, performing a cyclization reaction until by sampling inspection, a refraction coefficient of a sample at a temperature of 20 DEG C is 1.4720 to 1.4723 and the sample has fragrance of isopulegol, and discharging to obtain the isopulegol; and after gasifying the isopulegol, performing a dehydrogenation reaction at a temperature of 200 to 300 DEG C by a copper-nickel catalyst to obtain liquid thymol crystals of which a refraction coefficient at a temperature of 20 DEG C is 1.4850 to 1.5100. Compared with the prior art, the preparation method has the following beneficial effect that the thymol crystals, which are prepared by the method, overcome the harsh high-temperature and high-pressure conditions of a conventional friedel-crafts alkylation reaction, are mild in reaction temperature, use the recyclable catalyst and are environmental-friendly, are high in purity, and are kept stable in gloss, unchanged in odor and slightly reduced in content in the storage period.
公开/授权文献:
- CN105693471B 麝香草酚的制备方法 公开/授权日:2019-01-15
IPC结构图谱:
C | 化学;冶金 |
--C07 | 有机化学 |
----C07C | 无环或碳环化合物 |
------C07C37/00 | 有羟基或氧—金属基连接在六元芳环碳原子上化合物的制备 |
--------C07C37/06 | .非六元芳环或就地生成的六元芳环的转化,例如脱氢 |