The invention relates to an air purification nanofiber screen window and a manufacturing method thereof and belongs to the technical field of air purification and dust removal. According to the screen window, a graphene coating layer is attached to a glass fiber screen window framework, and the graphene coating layer is covered with a nanofiber film. The manufacturing method of the air purification nanofiber screen window comprises the steps that graphene dispersion liquid is prepared, the glass fiber screen window framework is soaked in an organic solvent to swell and then soaked in the graphene dispersion liquid, and the surface layer of the glass fiber screen window framework is coated with a layer of graphene; and electrostatic spinning liquid is prepared, the glass fiber screen window framework is spray-coated with the electrostatic spinning liquid through an electrostatic spinning device, a layer of nanofiber film is formed, and then fixation is conducted through a frame. The graphene arranged on the surface of the air purification nanofiber screen window framework in a coating mode can effectively adsorb pollution gases such as NH3, CO and NO2; and the nanofiber film covering the graphene can effectively filter out fine particulate matter such as smoke, pollen and PM2.5 in the air, and therefore the air purification nanofiber screen window has the functions of purifying the air and being beneficial to human health.