![一种高含量丹参素钠的制备方法](/CN/2015/1/194/images/201510973647.jpg)
基本信息:
- 专利标题: 一种高含量丹参素钠的制备方法
- 专利标题(英):Preparation method of high-content salvianic acid A sodium
- 申请号:CN201510973647.7 申请日:2015-12-22
- 公开(公告)号:CN105566092A 公开(公告)日:2016-05-11
- 发明人: 叶湘武 , 罗斌 , 马贤鹏 , 冯世明 , 赵曲
- 申请人: 贵州景峰注射剂有限公司 , 上海景峰制药有限公司
- 申请人地址: 贵州省贵阳市乌当区高新路158号
- 专利权人: 贵州景峰注射剂有限公司,上海景峰制药有限公司
- 当前专利权人: 贵州景峰注射剂有限公司,上海景峰制药有限公司
- 当前专利权人地址: 贵州省贵阳市乌当区高新路158号
- 代理机构: 上海天翔知识产权代理有限公司
- 代理人: 吕伴
- 主分类号: C07C51/41
- IPC分类号: C07C51/41 ; C07C59/52
The invention discloses a preparation method of high-content salvianic acid A sodium. The preparation method is characterized in that hot acid water extraction is performed on salviae miltiorrhizae, and a salt formation method by heating sodium hydroxide is used coordinately. The preparation method has the advantages that problems that many impurities exist, salvianic acid A is severely damaged, transfer rate is low, many purifying procedures are needed, the process is complex, the period is long, impurity removing is not thorough, the finished-product extract is low in salvianic acid A sodium content, and stability is poor caused by high-temperature decoction reflux extraction and high-temperature concentration are avoided effectively; oxidized and degraded salvianic acid A during extraction can be reduced, the salvianic acid A transfer rate in extract and salvianic acid A sodium stability are increased, the salvianic acid A is prevented from being destroyed by high temperature, no antioxidant is added, the storage stability of the salvianic acid A sodium is guaranteed in an acid environment, and the method is easy in operation implementation and suitable for large-scale industrial production.
IPC结构图谱:
C | 化学;冶金 |
--C07 | 有机化学 |
----C07C | 无环或碳环化合物 |
------C07C51/00 | 羧酸或它们的盐、卤化物或酐的制备 |
--------C07C51/41 | .羧酸盐的制备,用酸或它们的盐转变为带相同的羧酸部分的盐 |