基本信息:
- 专利标题： 一种包载核酸药物的具缺氧响应能力和放疗增敏功能脂质体
- 专利标题（英）：Lipidosome with entrapment nucleic acid drugs, anaerobic response capability and radiotherapy sensitivity enhancing function
- 申请号：CN201610026007.X 申请日：2016-01-15
- 公开(公告)号：CN105534908A 公开(公告)日：2016-05-04
- 发明人： 刘洪梅 , 于如同 , 李冠华 , 张亚飞 , 蔡一帆 , 周秀萍 , 解彦东 , 李白杨
- 申请人： 徐州医学院
- 申请人地址： 江苏省徐州市铜山路209号
- 专利权人： 徐州医学院
- 当前专利权人： 徐州医学院
- 当前专利权人地址： 江苏省徐州市铜山路209号
- 代理机构： 徐州市三联专利事务所
- 代理人： 周爱芳
- 主分类号： A61K9/127
- IPC分类号： A61K9/127 ; A61K48/00 ; A61K31/7088 ; A61K47/22 ; A61K47/24 ; A61P35/00 ; A61P7/04
The invention discloses a lipidosome with entrapment nucleic acid drugs, an anaerobic response capability and a radiotherapy sensitivity enhancing function. The lipidosome comprises a lipidosome body and nucleic acid drugs. The lipidosome is prepared from, by mass, 20-80% of lipid molecules with the radiotherapy sensitivity enhancing function, 5-50% of cholesterol, 3-50% of polyethylene glycol phospholipid and 1-30% of DOPC lipid molecules. The N/P ratio of the lipidosome to nucleic acid in the nucleic acid drugs is 1:(1-20). The obtained lipidosome overcomes the defects that the positive ion lipidosome toxicity is high, the blood stability is poor and the transfection efficiency is low, the effect of the nucleic acid drugs is effectively improved, meanwhile the lipidosome has the high endosome escape capability under the oxygen-deficient environment, so that the obvious advantage of transfection of gene-based drugs is achieved. The lipidosome is applicable to entrapment of various nucleic acid drugs, and the applicable dosage form range is wide.
公开/授权文献:
- CN105534908B 一种包载核酸药物的具缺氧响应能力和放疗增敏功能脂质体 公开/授权日：2018-12-14
IPC结构图谱:
| A | 人类生活必需 |
| --A61 | 医学或兽医学；卫生学 |
| ----A61K | 医用、牙科用或梳妆用的配制品 |
| ------A61K9/00 | 以特殊物理形状为特征的医药配制品 |
| --------A61K9/10 | .分散液；乳剂 |
| ----------A61K9/127 | ..脂质体 |