基本信息:
- 专利标题： 预后分类与治疗腺体癌症的方法
- 专利标题（英）：Methods of prognostically classifying and treating glandular cancers
- 申请号：CN201480028768.8 申请日：2014-05-16
- 公开(公告)号：CN105473772A 公开(公告)日：2016-04-06
- 发明人： 蔡坤志 , 李其融 , 徐中济
- 申请人： 财团法人国家卫生研究院
- 申请人地址： 中国台湾苗栗县
- 专利权人： 财团法人国家卫生研究院
- 当前专利权人： 财团法人国家卫生研究院
- 当前专利权人地址： 中国台湾苗栗县
- 代理机构： 永新专利商标代理有限公司
- 代理人： 左路
- 优先权： 61/824,679 2013.05.17 US
- 国际申请： PCT/US2014/038504 2014.05.16
- 国际公布： WO2014/186773 EN 2014.11.20
- 进入国家日期： 2015-11-17
- 主分类号： C40B30/04
- IPC分类号： C40B30/04 ; C12Q1/68 ; C07K16/00
This disclosure includes the identification of molecular markers, including ASPM, ATP9A, ACOX3, CDC45L, SLC40A1, AGR2, and those found in TABLE 2, that are associated with the differentiation and the clinical prognosis of pancreatic cancer. More specifically, the disclosure includes the identification of sets of gene markers whose expression levels can be used to distinguish pancreatic cancers with higher degrees of differentiation from those with lower degrees of differentiation. These markers can be used to predict clinical prognosis of pancreatic cancer, including disease progression, recurrence or death of the hosts. The disclosure also provides methods of treating glandular cancers and kits for assaying glandular cancers, such as pancreatic cancer, breast cancer, and prostate cancer, by inhibiting the expression of ASPM or its ability to activate or maintain the Wnt signaling activity and/or the cancer stem cell populations of said glandular cancers.
IPC结构图谱:
| C | 化学；冶金 |
| --C40 | 组合技术 |
| ----C40B | 组合化学；化合物库，如化学库、虚拟库 |
| ------C40B30/00 | 筛选化合物库的方法 |
| --------C40B30/04 | .通过测定对靶分子特殊结合能力，如抗体－抗原结合、受体－配体结合能力 |