基本信息:
- 专利标题： 一种碘醚柳胺的制备方法
- 专利标题（英）：A preparing method of rafoxanide
- 申请号：CN201510795439.2 申请日：2015-11-18
- 公开(公告)号：CN105461582A 公开(公告)日：2016-04-06
- 发明人： 吴中华 , 张小朋 , 陈贵才 , 徐天华 , 何奇雷 , 闻鸣
- 申请人： 浙江汇能生物股份有限公司
- 申请人地址： 浙江省嘉兴市海宁市长安镇(农发区)春潮路3号
- 专利权人： 浙江汇能生物股份有限公司
- 当前专利权人： 浙江汇能生物股份有限公司
- 当前专利权人地址： 浙江省嘉兴市海宁市长安镇(农发区)春潮路3号
- 代理机构： 杭州赛科专利代理事务所
- 代理人： 毛斌
- 主分类号： C07C231/02
- IPC分类号： C07C231/02 ; C07C235/64
A preparing method of rafoxanide is provided. The method includes preparing 2-chloro-4-nitrophenyl tert-chlorophenyl ether by adopting p-chlorophenol and 3,4-dichloronitrobenzene as raw materials and adopting DMF as a solvent under catalysis of a catalyst that is cuprous chloride, preparing 4-amino-2-chlorophenyl tert-chlorophenyl ether by hydrogenating under catalysis of a 10% Pd/C catalyst, reacting 3,5-diiodosalicylic acid that is adopted as a raw material with an acyl chlorination reagent that is BTC/C2H4Cl2 to prepare 3,5-diiodosalicyloyl chloride, and subjecting the 4-amino-2-chlorophenyl tert-chlorophenyl ether and the 3,5-diiodosalicyloyl chloride to condensation to prepare the rafoxanide. The method is mild in reaction conditions, simple in process and easy in operation. A product of the method is high in purity and high in yield. The method is suitable for industrial production.
IPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07C | 无环或碳环化合物 |
| ------C07C231/00 | 羧酸酰胺的制备 |
| --------C07C231/02 | .通过与氨或胺反应从羧酸或从它们的酯、酐或卤化物来制备 |