![一种用陶瓷膜去除粗品肝素钠中杂质的方法](/CN/2015/1/194/images/201510973548.jpg)
基本信息:
- 专利标题: 一种用陶瓷膜去除粗品肝素钠中杂质的方法
- 专利标题(英):Method for removing impurities in crude heparin sodium by using ceramic membrane
- 申请号:CN201510973548.9 申请日:2015-12-23
- 公开(公告)号:CN105418807A 公开(公告)日:2016-03-23
- 发明人: 刘冠男 , 宋延超 , 夏衬来
- 申请人: 青岛九龙生物医药有限公司
- 申请人地址: 山东省青岛市崂山区株洲路97号
- 专利权人: 青岛九龙生物医药有限公司
- 当前专利权人: 青岛九龙生物医药有限公司
- 当前专利权人地址: 山东省青岛市崂山区株洲路97号
- 主分类号: C08B37/10
- IPC分类号: C08B37/10
The present invention discloses a method for removing impurities in crude heparin sodium by using a ceramic membrane. According to the method, a dynamic cross-flow filtration manner is adopted. Enzymatic hydrolysate flows on a surface of an inside membrane of a ceramic membrane tube at a certain high flow velocity. The enzymatic hydrolysate flows through a microporous membrane along a direction perpendicular to the ceramic membrane. Macromolecule proteins are retained by the membrane, so that the enzymatic hydrolysate is separated from impurities and purified. The method of the present invention has high separating precision and high filtrating efficiency with the advantages of clear enzymatic hydrolysate, lower impurity content, free of heparin loss, convenient later adsorption, and the like. A product yield can reach 99.5%. Production costs are reasonable. Therefore, the method is suitable for large-scale industrial production.
IPC结构图谱:
C | 化学;冶金 |
--C08 | 有机高分子化合物;其制备或化学加工;以其为基料的组合物 |
----C08B | 多糖类;其衍生物 |
------C08B37/00 | 不包括在C08B1/00至C08B35/00组内的多糖类的制备;其衍生物 |
--------C08B37/10 | .肝素;它的衍生物 |