
基本信息:
- 专利标题: 氢化可的松的制备方法
- 专利标题(英):Method for preparing hydrocortisone
- 申请号:CN201510787666.0 申请日:2015-11-17
- 公开(公告)号:CN105367618A 公开(公告)日:2016-03-02
- 发明人: 廖俊 , 付林 , 曾建华 , 李桂莲 , 徐明琴 , 刘玉亭
- 申请人: 华中药业股份有限公司
- 申请人地址: 湖北省襄樊市岘山路118号
- 专利权人: 华中药业股份有限公司
- 当前专利权人: 华中药业股份有限公司
- 当前专利权人地址: 湖北省襄樊市岘山路118号
- 主分类号: C07J5/00
- IPC分类号: C07J5/00
The invention relates to a method for preparing hydrocortisone. The method includes: subjecting a cortisone acetate raw material to sites No. 3,20-keto protective reaction, site No.11-keto reduction reaction, site No.21-hydroxy esterification reaction, sites No. 3,20-ketone deprotection reaction, and site No. 21-acetate hydrolysis to obtain hydrocortisone. The method provides a new synthetic route containing esterification and deprotection in order, greatly improves the reaction selectivity, easily separates deprotection reaction products and avoids the posttreatment of tedious several times of extraction of a large amount of solvents in the traditional deprotection reaction process, and also avoids the side reaction caused by quenching reaction in the posttreatment of the traditional process; and the ester hydrolysis reaction is carried out under protection of inert gases in a mixed solvent, so as to avoid by-products produced in the hydrolysis reaction. The process route of the invention is novel, simple for operation, low in production cost, and applicable to industrial scale production.