The invention discloses an anti-theft tobacco turnover box. The anti-theft tobacco turnover box comprises a big-end-up trapezoid box body, wherein a rectangular frame is arranged above the trapezoid box body, a square hole is formed in each of two short edges of the frame, a box cover assembly is arranged on the frame, and a lock seal is arranged between the box cover assembly and each square hole. The lock seals are added to the position between the trapezoid box body and the box cover assembly of the tobacco turnover box, the safety during transportation and turnover of the tobacco turnover box is effectively improved, and the authenticity and the accuracy of articles and the number of the articles in the tobacco turnover box are guaranteed; meanwhile, positioning bosses are added to cover plates of the box cover assembly, stacking of the tobacco turnover box bodies is facilitated, and the stability during stacking is enhanced.