
基本信息:
- 专利标题: 一种对甲苯磺酸索拉非尼的制备方法
- 专利标题(英):Preparation method of sorafenib tosylate
- 申请号:CN201510862797.0 申请日:2015-11-30
- 公开(公告)号:CN105272911A 公开(公告)日:2016-01-27
- 发明人: 陈雨 , 马少红 , 王彦锋
- 申请人: 山东罗欣药业集团股份有限公司
- 申请人地址: 山东省临沂市罗庄区罗七路18号
- 专利权人: 山东罗欣药业集团股份有限公司
- 当前专利权人: 山东罗欣药业集团恒欣药业有限公司
- 当前专利权人地址: 山东省临沂市罗庄区罗七路18号
- 主分类号: C07D213/81
- IPC分类号: C07D213/81
The invention relates to a preparation method of sorafenib tosylate. The preparation method comprises the steps of reacting propylene chloroformate (5) with low cost and 4-chloro-3-trifluoromethyl phenylamine (2) with low cost to generate activated ester (6); reacting activated ester and 4-(4-aminophenoxy)-N-methyl-2-pyridine carboxamide (3) under the catalysis of N-methylpyrrolidine to obtain sorafenib with high yield; carrying out simple aftertreatment on the reaction to obtain sorafenib with relatively high purity; and then, reacting sorafenib and p-toluene sulphonic acid to generate the target product. The method is low in cost, simple in operation, few in reaction step, short in period, low in energy consumption, safe in process, free of high-toxicity reagents and suitable for industrial production, and the obtained product is high in yield and purity and free of potential safety problems.
公开/授权文献:
- CN105272911B 一种对甲苯磺酸索拉非尼的制备方法 公开/授权日:2018-11-06
IPC结构图谱:
C | 化学;冶金 |
--C07 | 有机化学 |
----C07D | 杂环化合物 |
------C07D213/00 | 杂环化合物,含六元环、不与其他环稠合、有1个氮原子作为仅有的杂环原子、环原子间或环原子与非环原子间有3个或更多个双键 |
--------C07D213/02 | .环原子间或环原子与非环原子间有3个双键 |
----------C07D213/04 | ..在环氮原子与非环原子间没有键或只有氢或碳原子直接连在环氮原子上 |
------------C07D213/06 | ...除了环氮原子外,只含氢和碳原子 |
--------------C07D213/62 | ....氧或硫原子 |
----------------C07D213/81 | .....酰胺;酰亚胺 |