The invention relates to a dexibuprofen enteric-coated and sustained-release tablet. The dexibuprofen enteric-coated and sustained-release tablet comprises a tablet core with a sustained release effect and a coating for coating the table core, wherein the tablet core is prepared from the following components: 70-90 parts of dexibuprofen, 10-30 parts of sustained-release skeleton stabilizer, 0-10 parts of filler, 0.2-1.5 parts of lubricating agent and 0.2-1.5 parts of flow aid; the effective quantity of active ingredient dexibuprofen takes more than 70% of the weight of table core. The invention has the advantages of excellent formula, reliable preparation process and easiness in industrial production; the prepared enteric-coated and sustained-release tablet in-vitro dissolution experiment shows: the releasing rate of gastric juice in 2 hours is smaller than 10%, which meets the requirements; the releasing rate of intestinal juice in 2 hours is 25-55%, the accumulative releasing rate in 4 hours is 50-80%, the accumulative releasing rate in 8 hours is more than 80%, and therefore, the releasing effect is excellent. The dexibuprofen enteric-coated and sustained-release tablet has effects of undissolving in the stomach and slowly releasing in the intestines so as to prevent irritation to the stomach and prolong the in-vivo releasing time of medicines simultaneously; the dexibuprofen enteric-coated and sustained-release tablet facilitates absorption to human bodies and has lasting effects.