基本信息:
- 专利标题： 一种拮抗空肠弯曲杆菌及抑制其flaA基因表达的植物乳杆菌
- 专利标题（英）：Lactobacillus plantarum capable of antagonizing campylobacter jejuni and inhibiting expression of flaA gene of campylobacter jejuni
- 申请号：CN201510777864.9 申请日：2015-11-13
- 公开(公告)号：CN105238727A 公开(公告)日：2016-01-13
- 发明人： 陈卫 , 田丰伟 , 张婷婷 , 翟齐啸 , 赵建新 , 王刚 , 张秋香 , 刘小鸣 , 张白曦 , 张灏
- 申请人： 江南大学
- 申请人地址： 江苏省无锡市蠡湖大道1800号
- 专利权人： 江南大学
- 当前专利权人： 江南大学
- 当前专利权人地址： 江苏省无锡市蠡湖大道1800号
- 代理机构： 哈尔滨市阳光惠远知识产权代理有限公司
- 代理人： 耿晓岳
- 生物保藏信息： CGMCC No.11445 20150924
- 主分类号： C12N1/20
- IPC分类号： C12N1/20 ; A61K35/747 ; A61P31/04 ; A23C9/123 ; A23L1/29 ; A23L1/218 ; C12R1/25
The invention discloses lactobacillus plantarum. The Lactobacillus plantarum can antagonize campylobacter jejuni and inhibit expression of a flaA gene of the campylobacter jejuni, has the good acid resistance and bile salt resistance, can inhibit growth of the campylobacter jejuni in vitro and has the good adhesive capacity on the intestinal epithelial cells. A fermentation supernatant of the lactobacillus plantarum enables the expression amount of the flaA gene of the campylobacter jejuni to be reduced by 8.2 times compared with a control group in vitro, and synthesis of campylobacter jejuni flagella is effectively inhibited; the lactobacillus plantarum enables the expression amount of the flaA gene of the campylobacter jejuni to be reduced by 1.7 times compared with a control group in a cell model. The lactobacillus plantarum can be used for preparing medicine for preventing and treating diseases caused by the campylobacter jejuni and participate in preparing fermentation milk products and the like and has the wide application prospect.
公开/授权文献:
- CN105238727B 一种拮抗空肠弯曲杆菌及抑制其flaA基因表达的植物乳杆菌 公开/授权日：2019-01-11