基本信息:
- 专利标题： 表达鼠伤寒沙门菌OmpL蛋白的重组猪痘病毒载体疫苗
- 申请号：CN201510452639.8 申请日：2015-07-28
- 公开(公告)号：CN105132437B 公开(公告)日：2018-06-08
- 发明人： 范红结 , 周红 , 蔺辉星 , 方一臻
- 申请人： 南京农业大学 , 南京昌吉生物科技有限公司
- 申请人地址： 江苏省南京市溧水区白马镇国家农业科技园南京农业大学基地
- 专利权人： 南京农业大学,南京昌吉生物科技有限公司
- 当前专利权人： 南京农业大学,南京昌吉生物科技有限公司
- 当前专利权人地址： 江苏省南京市溧水区白马镇国家农业科技园南京农业大学基地
- 代理机构： 南京天华专利代理有限责任公司
- 代理人： 徐冬涛; 杨秀丽
- 主分类号： C12N15/31
- IPC分类号： C12N15/31 ; C12N15/63 ; C12N15/863 ; C12N7/01 ; A61K48/00 ; A61K39/112 ; A61P31/04
The invention belongs to the field of biological products and provides a coding gene of salmonella typhimurium outer membrane protein L, a transfer vector pUSG11/P28-OmpL with the coding gene, a recombinant swinepox virus rSPV-OmpL and application and a preparation method of the recombinant swinepox virus rSPV-OmpL. The sequence of the coding gene is shown as SEQ ID NO.1, and the recombinant swinepox virus is obtained by insertion of the salmonella typhimurium outer membrane protein L into swinepox virus VR-363. A recombinant swinepox virus vaccine rSPV-OmpL is capable of greatly expressing target protein OmpL in immune animal bodies to induce in-vivo generation of high-potency antibodies aiming at OmpL in the immune animal bodies, the immune animals can be well protected, and the immune protective rate is up to 80% as for mice. In addition, the vaccine integrates advantages of excellent immune effects of attenuated vaccines and high safety of inactivated vaccines, thereby being an ideal novel vaccine.
公开/授权文献:
- CN105132437A 表达鼠伤寒沙门菌OmpL蛋白的重组猪痘病毒载体疫苗 公开/授权日：2015-12-09