The invention discloses a traditional Chinese medicinal composition for treating mink diarrhea and a preparation method of the traditional Chinese medicinal composition, and belongs to the field of traditional Chinese medicine treatment of mink diarrhea. The traditional Chinese medicinal composition for treating mink diarrhea disclosed by the invention is prepared from the following various medicinal raw materials: loquat leaf, blackberrylily rhizome, swamp mahogany leaf, radix sophorae flavescentis, caulis akebiae, coix seed, mirabilite, ligusticum wallichii and fresh ginger. The invention further discloses a method for preparing the traditional Chinese medicinal composition, wherein the method comprises the following steps: (1) weighing the various medicinal raw materials according to the proportions; (2) adding water and soaking the raw materials, decocting, filtering, removing dregs and reserving filtrate so as to obtain the traditional Chinese medicinal composition. The traditional Chinese medicinal composition disclosed by the invention has functions of clearing away heat and toxic materials, cooling blood and stopping diarrhea, relieving diarrhea with astringents and invigorating qi and blood; the traditional Chinese medicinal composition is capable of significantly enhancing the resistance and immunity of minks and effectively resisting mink diarrhea caused by parvovirus infection or mixed infection of various bacteria; and the traditional Chinese medicinal composition is high in cure rate, free from reoccurrence after curing, free from influence on the quality of mink fur and free from any toxic or side effect.