The invention discloses an industrial control system safe support framework and a data safe transmission and storage method thereof. The safe support framework comprises a plurality of safe servers provided with safe chips, and a plurality of clients provided with safe chips, wherein the clients and the safe servers are in connection over the network; the servers are provided with an industrial control system credible environment control platform server, a credible mobile medium control system server, a credible industrial control firewall server and a credible database system; the clients are provided with a credible industrial control system firewall client, a credible environment control platform client, and a credible mobile medium control system client, wherein the credible database system is responsible for providing confidentiality and integrity protection service for the setting sensitive data stored in a database, and binding the setting sensitive data with a credible industrial control system environment. The framework and the data safe transmission and storage method thereof can prevent malicious codes from operating and broadcasting in an industrial control environment, and meanwhile avoid sensitive data leakage and tampering.