
基本信息:
- 专利标题: 一种利用树脂吸附发酵原液提取林可霉素的方法
- 专利标题(英):Method for extracting lincomycin by using resin to adsorb fermentation stock solution
- 申请号:CN201510295548.8 申请日:2015-06-02
- 公开(公告)号:CN104861007A 公开(公告)日:2015-08-26
- 发明人: 吕祖平 , 贾坤 , 周树林 , 季海鸣 , 苗玉武
- 申请人: 江苏海阔生物医药有限公司
- 申请人地址: 江苏省盐城市滨海县沿海化工园区中山路
- 专利权人: 江苏海阔生物医药有限公司
- 当前专利权人: 景德镇富祥生命科技有限公司
- 当前专利权人地址: 江苏省盐城市滨海县沿海化工园区中山路
- 代理机构: 北京市广友专利事务所有限责任公司
- 代理人: 耿小强
- 主分类号: C07H15/16
- IPC分类号: C07H15/16 ; C07H1/06
The invention discloses a method for extracting lincomycin lincomycin by using resin to adsorb a fermentation stock solution. The method comprises the following steps: (1), placing a fermentation solution in a pretreatment tank, adding a sodium hydroxide solution whiling stirring, heating, adding resin and stirring slowly to obtain filtered resin; (2) placing the filtered resin into alkaline water with the same volume, and adding deionized water to clean the resin; (3), placing the cleaned resin in a chromatographic column and eluting the resin with n-butyl alcohol; (4), taking lincomycin desorbed solution and adding activated carbon for decolorizing; (5) desalinating the decolorized liquid through a desalinating column to obtain lincomycin desalinating liquid; (6), concentrating; (7) drying to obtain the finished product of hydrochloric acid lincomycin. The method provided by the invention avoids the procedures of plate-frame pressure filtration or ceramic membrane filtration, solvent extraction, back extraction and the like in the traditional process, and has the advantages of being simple in operation, low in labor intensity, clean in working environment, simplified in process, small in occupied area, low in cost and small in environmental pollution; the total recovery is greater than 85%, and the purity of the finished product is greater than 98%.
公开/授权文献:
- CN104861007B 一种利用树脂吸附发酵原液提取林可霉素的方法 公开/授权日:2017-09-29
IPC结构图谱:
C | 化学;冶金 |
--C07 | 有机化学 |
----C07H | 糖类;及其衍生物;核苷;核苷酸;核酸 |
------C07H15/00 | 含有直接连在糖化物基团的杂原子上的烃基或取代烃基的化合物 |
--------C07H15/02 | .未被环状结构取代的无环基团 |
----------C07H15/14 | ..连在糖化物基团的1个硫,硒或碲原子上 |
------------C07H15/16 | ...林肯霉素;它的衍生物 |