The invention relates to an IPv6-based video monitoring and radio frequency identification two-dimensional code system and method in transformer station inspection. The system is composed of a video monitoring module and a radio frequency identification two-dimensional code module; the video monitoring module is composed of a monitoring scheduling center and monitoring centers and monitoring devices at various levels from top to the bottom; and the radio frequency identification two-dimensional code module is composed of a two-dimensional code module, a radio frequency front end and a processing center. The system provided by the invention provides such video monitoring tasks as equipment monitoring, personnel operation monitoring, operation maintenance monitoring and the like for an electric power communication industry, and realizes regular in-place inspection examination of electric power equipment especially a transformer station, thereby being an important guarantee of safe and stable operation of a power system. Defects and faults can be timely discovered through the transformer station inspection, the video monitoring module employs an IPv6 communication protocol for network communication, and the data security and the data transformation performance are improved. The system provided by the invention is simple and complete and is good in expansion performance and reliable in operation, thereby having quite good popularization and application prospect.