The invention discloses a purification method of high-purity polysaccharides of cistanche deserticola. The method comprises is characterizing by comprising processes as follows: firstly, cistanche deserticola coarse powder is added to hot water and subjected to reflux for 2 h at the temperature of 60 DEG C-90 DEG C, an extracting solution is obtained after filtration washing and then is left to stand, cooled and filtered, filtrate is subjected to decoloration and purification through macroporous resin, an effluent liquid passes by ion resin, a polysaccharide solution is obtained, and finally, the high-purity polysaccharides of the cistanche deserticola is obtained after spraying drying. According to the purification method, the procedure is clear, the method is simple, the cost is low, no environmental pollution is caused, a product obtained through purification has good color, high yield and purity and is suitable for industrial mass production, characteristics of different types of pigments and impurities of the cistanche deserticola are sufficiently applied, the high-purity polysaccharide component is obtained, and a basis is provided for wider and effective application of polysaccharides of the cistanche deserticola.