The invention discloses a method and a device for determining parameters of a feed forward controller of a coordination system. The method comprises the following steps: carrying out machine set property modeling according to a machine set thermodynamic property disturbance test; designing the feed forward controller according to a modeling result and parameters under various working conditions of a machine set in a power plant DCS historical database; determining the parameters of the feed forward controller according to steady-state parameters, constant load variable pressure tests and constant pressure variable load tests under the various working conditions of the machine set in the power plant DCS historical database; after performing DCS logic constitution on the feed forward controller and the parameters of the feed forward controller, and assembling the feed forward controller on a power plant DCS system, carrying out variable load tests at different rates, and adjusting the parameters of the feed forward controller according to the test results to enable the machine set to meet the operation demands in a variable load process. The frequency modulation and peak regulation performance, the safety and the stability of the machine set are solved fundamentally, and the economical efficiency of the machine set is improved greatly.