The invention discloses a fracture-cavity type oil and gas reservoir natural driving energy three-dimensional simulation experiment set. The experiment set is mainly composed of a cubic glass slot, and an oil and gas reservoir simulation unit, a water injection simulation unit, a gas injection simulation unit, an oil injection simulation unit, a data collecting simulation unit and an image collecting simulation unit which are respectively connected with the cubic glass slot. The oil and gas reservoir simulation unit comprises an oil and gas reservoir model and a shaft; the water injection simulation unit comprises a water tank, a water pump, a pressure bearing water tank, and a metal pipe; the gas injection simulation unit comprises an air compressor, a gas storage pot, an emptying valve, a draining filter and a cold dryer; the oil injection simulation unit comprises an oil tank, a pressure bearing oil tank, a metal pipe and an oil pump; the data collecting simulation unit comprises a flow meter and a pressure gage; a particle imaging testing system of the image collecting simulation unit is installed on a mobile slide rod at outside of the cubic glass slot. The fracture-cavity type oil and gas reservoir natural driving energy three-dimensional simulation experiment set is reasonable and visible in structural design, and can carry out the three-dimensional simulation experiment study of the oil and gas reservoir exploration under the function of complex natural energy.