The invention discloses a high-voltage switch cabinet of a frame structure. The high-voltage switch cabinet comprises uprights, cross beams and shell plates, each of the uprights and the cross beams is of a profile structure, a T-shaped groove used for positioning and mounting a bolt for the T-shaped groove is formed in the side wall of each of the uprights and the cross beams, a mounting folded edge is arranged on a mounting lateral side of the shell plate and fixedly mounted on the upright and/or the cross beam through the bolt for the T-shaped groove, and the uprights and the cross beams are connectedly fixed through screws and/or connecting plates. The technical scheme that a cabinet body is formed by setting up a framework of the cabinet body by adopting profiles and using the shell plate to cover the surface of the framework is adopted, so that the problems of high labor intensity, low efficiency, low strength and difficulty in assembly construction in the prior art are solved; the framework set up by the the profiles are higher in strength, higher in assembly accuracy and more attractive, and the high-voltage switch cabinet is suitable for power systems.