基本信息:
- 专利标题： 一种合成2-卤代-3-频那醇硼酸酯-5-氯苯胺的方法
- 申请号：CN201410689664.3 申请日：2014-11-27
- 公开(公告)号：CN104402920B 公开(公告)日：2018-04-03
- 发明人： 薛峰 , 李长恭 , 祝勇 , 李永芳 , 崔茂金 , 王九霞 , 邓月娥
- 申请人： 河南科技学院
- 申请人地址： 河南省新乡市华兰大道东段
- 专利权人： 河南科技学院
- 当前专利权人： 河南科技学院
- 当前专利权人地址： 河南省新乡市华兰大道东段
- 代理机构： 北京汉昊知识产权代理事务所
- 代理人： 冯谱
- 主分类号： C07F5/04
- IPC分类号： C07F5/04
The invention discloses a method for synthesizing 2-halogenated-3-pinacol borate-5-chloroaniline and belongs to the field of drug intermediate synthesis. The 2-halogenated-3-pinacol borate-5-chloroaniline is synthesized from 2-halogenated-5-chloro-nitrobenzene, which is used as a raw material and can be provided by the market through three steps of bromization, coupling and reduction; the method provided by the invention is faster in synthesis, simple and effective, and high in yield, and meanwhile, a coarse product obtained in each step can be directly used in the next step; since compared with an amino group, the nitro group is a strong electron withdrawing group, a method that coupling is performed and then reduction is performed in reaction is adopted, and the dosage of a catalyst can be reduced to 1-2 mol% in the second step of coupling, therefore, the reaction cost is further reduced.
公开/授权文献:
- CN104402920A 一种合成2-卤代-3-频那醇硼酸酯-5-氯苯胺的方法 公开/授权日：2015-03-11