The invention discloses a box body type workpiece shot blasting cleaning device for upper mobile material conveying. The box body type workpiece shot blasting cleaning device comprises a shot blasting chamber, shot blasters mounted on the shot blasting chamber, a shot and sand circulating system matched with the shot blasters and a shot and sand separator, wherein a workpiece inlet is formed in one side surface of the shot blasting chamber; the shot blasting cleaning device further comprises material conveying roller ways arranged at one side of the workpiece inlet of the shot blasting chamber and material feeding manipulators; each material feeding manipulator comprises a stander; a rail and a power trolley matched with the rail are arranged on the top of the stander; the direction of the rail is perpendicular to the material conveying roller ways; a lifting hook is perpendicularly mounted on the power trolley; the lower end of the lifting hook is opposite to the workpiece inlet of the shot blasting chamber; a rotary workbench is arranged in the shot blasting chamber; a clamp is arranged on the rotary workbench. The box body type workpiece shot blasting cleaning device is used for achieving multi-orientation and high-efficiency shot blasting treatment of a box body; the possibility of cleaning dead corners is reduced to minimum; the box body type workpiece shot blasting cleaning device is low in overall manufacturing cost, easy to operate, convenient to maintain and good in use effect.