The invention discloses a snake king medicine for treating dermatopathy and a preparation method thereof, the snake king medicine comprises the following components by weight percentage: 2-5% of monostearin, 5-8% of glycerin, 5-7% of Vaseline, 0.1-0.3% of ethyl ester, 0.2-0.3% of methyl esters, 3-5% of stearic acid, 3-5% of octadecanol, 1-2% of silicone oil, 1-3% of borneol, 0.6-0.8% of azone, 1-3% of peregal and 65-80% of purifying water. The provided snake king medicine is a white emulsifiable paste, and has the characteristics of no foreign impurity, no peculiar smell, special smell, fine paste body and lubrication. The provided snake king medicine is used for treating cutaneous pruritus, ringworm of the body, tinea cruris, manus and tinea pedis, acne, psoriasis and various dermatitis dermatopathy, The snake king medicine is externally applied medicine, and has the advantages of safety, no stimulation and no side effect.