The invention relates to an interaction method based on an Anylogic simulation model and GIS (Geographic Information System) environment. The interaction method comprises the following steps: determining an Agent state attribute, and defining an Agent behavior to control Agent; creating an Anylogic simulation model, and exporting the Anylogic simulation model in a file mode; uploading the obtained file-mode Anylogic simulation model onto the GIS environment; and under the GIS environment, calling the Anylogic simulation model for simulation through the Agent, and displaying a simulation result under the GIS environment. Under the GIS environment, Agent-based modeling can guarantee that internal information flows and can be dynamically presented in the GIS environment, certain specific Agent in the Agent-based modeling can be subjected to dynamic control so as to provide possibilities for recording and monitoring the specific Agent in real time in an simulation process, and the invention exhibits effectiveness and convenience when the invention is applied to the processes of emergency evacuation and the optimal configuration of resources.