The invention discloses a large opening car spoke type cable supported grid structure which comprises an upper chord rigid grid system and a lower chord tensioning cable-strut system. The upper chord rigid grid system is a structure with a large opening in the middle, and the lower chord tensioning cable-strut system comprises a strop and a plurality of radial tensioning cables, wherein the strop is correspondingly arranged below the opening of the upper chord rigid grid system, and the radial tensioning cables are arranged in a car spoke type in the radial direction of the strop. the end portion of each radial tensioning cable is hinged to the strop, a supporting rod is arranged between the radial tensioning cables and the upper chord rigid grid system in the arrangement direction of the redial tensioning cables, and a diagonal web member is arranged between the strop and the upper chord rigid grid system in the ring direction of the strop. By means of the large opening car spoke type cable supported grid structure, the high strength material characteristic of the tensioning cables is fully used, the cantilever stress state of the upper chord rigid grid system is changed to the stress state of an elastic support continuous beam, the rigidity of the overall structure is guaranteed, building material is saved, and the attractive architectural effect is achieved.