The invention provides an automatic test system and method for a transformer substation measurement and control device. The system comprises a test background server, an exchanger, a network tester, an intelligent tester, a three-phase standard meter, a controllable power source and a GPS clock module. The data exchanging is respectively carried out between the network tester and the test background server, between the intelligent tester and the test background server, between the three-phase standard meter and the test background server and between the controllable power source and the test background server through the exchanger, the test background server is in communication with the measurement and control device through the network protocol, the controllable power source is controlled to supply electricity to the measurement and control device, and time synchronism between the test background server and the measurement and control device is achieved through a GPS clock module. According to the automatic test system and method for the transformer substation measurement and control device, a test task can be automatically generated, detection steps can be automatically executed, detection reports can be automatically generated, the interference of artificial factors is reduced, the test randomness is removed, testing efficiency and testing reliability are improved, testing repeatability is achieved, the traceability of testing work is guaranteed, and the reliability and consistency of the test result are guaranteed.