The invention discloses a multi-valve regulation water supply system of a boiler. The multi-valve regulation water supply system comprises a liquid dispatching unit and a liquid circulating unit. The liquid dispatching unit comprises liquid stop valves and a liquid storage device, the liquid circulating unit comprises a pressure reducer, a coal economizer and a liquid pump, the units are connected with each other by a liquid pipeline, liquid in the liquid storage device flows into a steam drum, flows into a water cooling wall in the boiler and is heated to generate steam and water mixtures, and steam flows into a steam turbine, is expanded, does work and drives a power generator to generate power. The multi-valve regulation water supply system has the advantages that the liquid pump only needs to overcome resistance generated by the liquid which flows in the pipeline in water delivery procedures, accordingly, power consumption of the pump can be greatly reduced, and the power generation efficiency of a boiler system can be greatly improved.