基本信息:
- 专利标题： 一种循环水相体系中合成芳香伯胺的方法
- 专利标题（英）：Method for synthesizing aromatic primary amine in circulating water phase system
- 申请号：CN201310751904.3 申请日：2013-12-31
- 公开(公告)号：CN103739417A 公开(公告)日：2014-04-23
- 发明人： 朱新海 , 杨波 , 廖礼豪 , 曾永亨 , 万一千
- 申请人： 中山大学
- 申请人地址： 广东省广州市海珠区新港西路135号
- 专利权人： 中山大学
- 当前专利权人： 中山大学
- 当前专利权人地址： 广东省广州市海珠区新港西路135号
- 代理机构： 广州科粤专利商标代理有限公司
- 代理人： 莫瑶江
- 主分类号： C07B43/04
- IPC分类号： C07B43/04 ; C07D213/73 ; C07C209/10 ; C07C211/51 ; C07C211/52 ; C07C211/45 ; C07C211/46 ; C07C211/47 ; C07C213/02 ; C07C217/84 ; C07C221/00 ; C07C225/22 ; C07C227/08 ; C07C229/60 ; C07C231/12 ; C07C237/30
The invention discloses a method for synthesizing an aromatic primary amine in a circulating water phase system. According to the method, an aryl halide and ammonia water are taken as raw materials, water is taken as a solvent, a carbonate, a fluoride, a phosphate or a hydroxide of an alkali metal or an alkaline-earth metal or a compound which can be converted to a corresponding alkali in water is taken as the alkali, polyamine carboxylic acid and a salt type compound thereof are taken as ligands, and a copper source catalyst is adopted for catalyzing the formation of the aromatic primary amine from the aryl halide and the ammonia water. According to the method disclosed by the invention, the water is used as the solvent, any phase transfer of the catalyst is not required, and the catalyst, the ligands and the reaction solvent, namely the water, can be recycled, so that the environment-friendly property of reaction is effectively improved, the method is more in line with requirements of green chemical development, a substrate particularly has a wide range of applications, and the method further has broad prospects in the aspects of preparation of natural products, medicaments and pesticides.
公开/授权文献:
- CN103739417B 一种循环水相体系中合成芳香伯胺的方法 公开/授权日：2016-08-17
IPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07B | 有机化学的一般方法；所用的装置 |
| ------C07B43/00 | 含氮官能团的形成或引入 |
| --------C07B43/04 | .氨基 |