基本信息:
- 专利标题： 溴化烯炔化合物E-18-溴-5,7,15-三炔-17-烯十八酸酯的制备方法
- 专利标题（英）：Preparation method of brominated eneyne compound E-18-bromo-5,7,15-trialkynyl-17-ene stearate
- 申请号：CN201210347339.X 申请日：2012-09-17
- 公开(公告)号：CN103664605A 公开(公告)日：2014-03-26
- 发明人： 郭跃伟 , 王贺瑶 , 龚景旭
- 申请人： 中国科学院上海药物研究所
- 申请人地址： 上海市浦东新区张江祖冲之路555号
- 专利权人： 中国科学院上海药物研究所
- 当前专利权人： 中国科学院上海药物研究所
- 当前专利权人地址： 上海市浦东新区张江祖冲之路555号
- 代理机构： 北京金信立方知识产权代理有限公司
- 代理人： 朱梅; 王荣
- 主分类号： C07C69/65
- IPC分类号： C07C69/65 ; C07C67/343
The invention relates to a synthesis method of a long-chain brominated eneyne compound E-18-bromo-5,7,15-trialkynyl-17-ene stearate with lipid-lowering and slimming activity, of which the structural formula is disclosed in the specification. The method comprises the following steps: a. carrying out bromination reaction on a compound disclosed as Formula 2 and NBS (N-bromosuccinimide) under the action of silver nitrate to generate a compound disclosed as Formula 3; b. reacting the compound disclosed as Formula 3 with 1,9-decadiyne under the actions of amine, cuprous ion and hydroxylamine hydrochloride to generate a compound disclosed as Formula 4; and c. reacting the compound disclosed as Formula 4 with 1,2-ethylene dibromide under the catalytic actions of cuprous ion, a palladium reagent and amine to obtain the compound disclosed as Formula I. The synthesis method provided by the invention is novel in synthetic route and simple to operate.
公开/授权文献:
- CN103664605B 溴化烯炔化合物E-18-溴-5,7,15-三炔-17-烯十八酸酯的制备方法 公开/授权日：2015-12-09
IPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07C | 无环或碳环化合物 |
| ------C07C69/00 | 羧酸酯；碳酸酯或卤甲酸酯 |
| --------C07C69/612 | .羧酸酯，其羧基连接在非环碳原子上，且酸的部分含六元芳环 |
| ----------C07C69/65 | ..不饱和酸的 |