The invention provides a method for simulating direct current magnetic biasing of a transformer in a multi-direct-current-drop-point region. The method includes the following steps: determining a simulating model of a direct current magnetic biasing current flowing loop, determining whether direct current magnetic biasing restraining measures are required to be taken on the transformer or not according to transformer substation master substation neutral point direct current magnetic biasing current levels and change rules under different combination operating modes of multiple direct currents, determining the direct current magnetic biasing current restraining measures on the transformer, obtaining the optimal direct current magnetic biasing current restraining measures through simulation comparison, and determining parameters of a direct current magnetic biasing current restraining device corresponding to the optimal restraining measures. According to the method for simulating direct current magnetic biasing of the transformer in the multi-direct-current-drop-point region, the complexity of a power grid and a ground access in the multi-direct-current-drop-point region is considered, the transformer direct current magnetic biasing current levels under the different operating modes of the multiple direct currents are given, and therefore the effective method and the technical parameters for restraining direct current magnetic biasing of the transformer are provided.