The invention provides a receiving-end network voltage stabilization overall process situation assessment and prevention and control method based on responses. The method comprises the steps of S1, obtaining various off-line simulation data or real-time measuring data; S2, constructing equivalent power transmission models of nodes according to node practical transfer power; S3, obtaining a node quiescent voltage stability margin index Vsi of equivalent power transmission model parameters of each node; S4, constructing a node reactive compensation assessment index according to the equivalent power transmission model parameters of each node; S5, setting an early warning threshold value Ncr of the node quiescent voltage stability margin index, and calculating a load shedding estimation of a weaker node when the quiescent voltage stability margin index Vsi of each node is smaller than the Ncr. According to the receiving-end network voltage stabilization overall process situation assessment and prevention and control method based on the responses, a weak node or a weak area in a current operating mode can be found out, a rapid estimation of reactive compensation levels and load shedding of each node is achieved, and the method can be widely applied to the fields of power network planning and online security monitoring.