基本信息:
- 专利标题： 一种阿霉酮衍生物长循环纳米脂质载体及其制备方法
- 专利标题（英）：Amoitone derivative long-circulation nanometer lipid carrier and preparation method thereof
- 申请号：CN201310209554.8 申请日：2013-05-30
- 公开(公告)号：CN103263392A 公开(公告)日：2013-08-28
- 发明人： 张典瑞 , 栾晶晶 , 郝蕾蕾 , 李彩云 , 郭和坚 , 张连茹 , 徐庆妍 , 胡志钰
- 申请人： 山东大学
- 申请人地址： 山东省济南市历下区文化西路44号
- 专利权人： 山东大学
- 当前专利权人： 山东大学
- 当前专利权人地址： 山东省济南市历下区文化西路44号
- 代理机构： 济南圣达知识产权代理有限公司
- 代理人： 彭成
- 主分类号： A61K9/19
- IPC分类号： A61K9/19 ; A61K9/10 ; A61K31/216 ; A61K47/34 ; A61P35/00
The invention discloses an amoitone derivative long-circulation nanometer lipid carrier which comprises the following main components: crude medicine Amoitone B, polyoxyethylene glycol bisstearate, solid lipid material, liquid lipid material, fat-soluble emulsifier, water-soluble emulsifier and injection water. The preparation method of the amoitone derivative long-circulation nanometer lipid carrier is an emulsion evaporating-low temperature curing method. The amoitone derivative long-circulation nanometer lipid carrier prepared by the preparation method has a slow release function in the body, is capable of effectively prolonging the in-vivo retention time of the medicine and improving the bioavailability of the medicine, has higher encapsulation efficiency and medicine carrying amount and a grain size of about 200nm, and can be passively targeted to a liver tissue, so that the toxic and side effects of the Amoitone B are lowered. Moreover, the amoitone derivative long-circulation nanometer lipid carrier is good in biocompatibility, easy to degrade, good in stability and capable of improving body tolerance and patient compliance.
公开/授权文献:
- CN103263392B 一种阿霉酮衍生物长循环纳米脂质载体及其制备方法 公开/授权日：2015-08-19
IPC结构图谱:
| A | 人类生活必需 |
| --A61 | 医学或兽医学；卫生学 |
| ----A61K | 医用、牙科用或梳妆用的配制品 |
| ------A61K9/00 | 以特殊物理形状为特征的医药配制品 |
| --------A61K9/10 | .分散液；乳剂 |
| ----------A61K9/19 | ..冻干的 |