The invention provides a 2-amino-5-thiol-1, 3, 4-thiadiazole copper controlled-release microcapsule which comprises a capsule core and a capsule wall. The capsule core comprises 2-amino-5-thiol-1, 3, 4-thiadiazole copper, capsule core solvent and co-solvent. Components of the capsule wall comprise urea, formaldehyde solution and performed polymers. The 2-amino-5-thiol-1, 3, 4-thiadiazole copper controlled-release microcapsule is prepared in an emulsion polymerization mode. The 2-amino-5-thiol-1, 3, 4-thiadiazole copper controlled-release microcapsule has the advantages that in the process of application, inert ingredients, such as a wetting agent, do not need to be added, long-time action on a target object can be achieved; the problem that after the microcapsule application, due to ultraviolet light, illumination and raining, decomposition is affected is solved; after the application of the 2-amino-5-thiol-1, 3, 4-thiadiazole copper controlled-release microcapsule, the capsule core automatically releases the agents as time goes by, and tedious work, such as manual mist spray, in the process of production is reduced; under the environment of normal temperature and normal pressure, the microcapsule is stable in storage.