基本信息:
- 专利标题： 一种酰胺类化合物合成的新方法
- 专利标题（英）：New method for synthesizing amide compounds
- 申请号：CN201210516266.2 申请日：2012-12-06
- 公开(公告)号：CN103214386A 公开(公告)日：2013-07-24
- 发明人： 张炜 , 武侠 , 盛国柱 , 才秀华
- 申请人： 青岛农业大学
- 申请人地址： 山东省青岛市城阳区长城路700号青岛农业大学化学与药学院
- 专利权人： 青岛农业大学
- 当前专利权人： 青岛农业大学
- 当前专利权人地址： 山东省青岛市城阳区长城路700号青岛农业大学化学与药学院
- 主分类号： C07C231/10
- IPC分类号： C07C231/10 ; C07C233/65 ; C07C235/64 ; C07C233/66 ; C07C233/75 ; C07C233/81 ; C07C233/25
The invention relates to a method for synthesizing amide compounds. A nitro compound and aldehyde (mole ratio is 1:1-1.6) are used as reaction substrates, zinc dust (mole ratio of the zinc dust to the nitro compound is 2-4:1) is used as a catalyst and a reducing agent, acetate or ammonium chloride (mole ratio of the acetate or the ammonium chloride to the nitro compound is 8-2:1) is used as a reaction medium, and methanol, ethanol, acetonitrile, water, methanol/water, ethanol/water and acetonitrile/water are respectively used as solvents. The nitro compound is reduced to synthesizing amide by a one-kettle way under 20-70 DED C for 0.5-5h by stirring. The method of the invention has advantages of short reaction line, simple operation, mild condition, green and environmental protection, and has important meanings on amide bond formation research in organic chemistry, synthesis research of peptide medicaments, and amide bond formation research in pesticide synthesis.
公开/授权文献:
- CN103214386B 一种酰胺类化合物合成的方法 公开/授权日：2014-08-13
IPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07C | 无环或碳环化合物 |
| ------C07C231/00 | 羧酸酰胺的制备 |
| --------C07C231/10 | .从不包含在C07C231/02至C07C231/08各组中的化合物制备 |