基本信息:
- 专利标题： 一种两亲性羧甲基葡聚糖修饰的磁性脂质体及其制备和应用方法
- 专利标题（英）：Amphipathic carboxymethyl glucan-modified magnetic lipidosome, and preparation and application methods thereof
- 申请号：CN201310133817.1 申请日：2013-04-17
- 公开(公告)号：CN103191060A 公开(公告)日：2013-07-10
- 发明人： 李娟 , 刘又年 , 郭红艳 , 孙晓毅 , 曾科 , 王建秀
- 申请人： 中南大学
- 申请人地址： 湖南省长沙市岳麓区麓山南路932号
- 专利权人： 中南大学
- 当前专利权人： 中南大学
- 当前专利权人地址： 湖南省长沙市岳麓区麓山南路932号
- 代理机构： 长沙市融智专利事务所
- 代理人： 袁靖
- 主分类号： A61K9/127
- IPC分类号： A61K9/127 ; A61K47/36 ; A61K47/02 ; A61K49/06 ; A61K31/704 ; A61P35/00
The invention belongs to the field of a nanotechnology and in particular relates to an amphipathic carboxymethyl glucan-modified magnetic lipidosome, and preparation and application methods thereof. The magnetic lipidosome is prepared by a film ultrasonic dispersion method and the surface of the magnetic lipidosome is modified by amphipathic carboxymethyl glucan, so high stability is achieved. The amphipathic carboxymethyl glucan can be synthesized by oleylamine and glucan. The magnetic lipidosome has small grain size, dispersion uniformity, high stability and high magnetic responsiveness. The magnetic lipidosome can serve as a thermal therapy medium and a nuclear magnetic resonance imaging contrast agent and also can be used for carrying medicines in a targeted mode and controllably releasing medicines. The magnetic lipidosome has simple and practical preparation process, low cost and excellent biocompatibility and biodegradability, accords with the requirements of green chemistry, and has a wide clinical application prospect.
公开/授权文献:
- CN103191060B 一种两亲性羧甲基葡聚糖修饰的磁性脂质体及其制备和应用方法 公开/授权日：2014-11-05
IPC结构图谱:
| A | 人类生活必需 |
| --A61 | 医学或兽医学；卫生学 |
| ----A61K | 医用、牙科用或梳妆用的配制品 |
| ------A61K9/00 | 以特殊物理形状为特征的医药配制品 |
| --------A61K9/10 | .分散液；乳剂 |
| ----------A61K9/127 | ..脂质体 |