基本信息:
- 专利标题： 程序性死亡-1(PD-1)的人单克隆抗体及使用抗PD-1抗体来治疗癌症的方法
- 申请号：CN201210554886.5 申请日：2006-05-02
- 公开(公告)号：CN103059138B 公开(公告)日：2015-10-28
- 发明人： 艾伦.J.科曼 , 莫汉.斯里尼瓦森 , 王常玉 , 马克.J.塞尔比 , 陈炳良 , 约瑟芬.M.卡达雷里 , 黄海春
- 申请人： 小野药品工业株式会社 , 梅达雷克斯有限责任公司
- 申请人地址： 日本大阪府
- 专利权人： 小野药品工业株式会社,梅达雷克斯有限责任公司
- 当前专利权人： 小野药品工业株式会社,E·R·施贵宝&圣斯有限责任公司
- 当前专利权人地址： 日本大阪府
- 代理机构： 北京市柳沈律师事务所
- 代理人： 岑晓东
- 优先权： 60/679,466 2005.05.09 US; 60/738,434 2005.11.21 US; 60/748,919 2005.12.08 US
- 分案原申请号： 2006800238600 2006.05.02
- 主分类号： C07K16/28
- IPC分类号： C07K16/28 ; A61K39/395 ; A61P35/00 ; C12N15/13 ; C12N15/63 ; C12N5/10
The present invention provides isolated monoclonal antibodies, particularly human monoclonal antibodies, that specifically bind to PD-1 with high affinity. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for detecting PD-1, as well as methods for treating various diseases, including cancer and infectious diseases, using anti-PD-1 antibodies. The present invention further provides methods for using a combination immunotherapy, such as the combination of anti-CTLA-4 and anti-PD-1 antibodies, to treat hyperproliferative disease, such as cancer. The invention also provides methods for altering adverse events related to treatment with such antibodies individually.
公开/授权文献:
- CN103059138A 程序性死亡-1(PD-1)的人单克隆抗体及使用抗PD-1抗体来治疗癌症的方法 公开/授权日：2013-04-24
IPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07K | 肽 |
| ------C07K16/00 | 免疫球蛋白，例如，单克隆或多克隆抗体 |
| --------C07K16/18 | .来自动物或人的抵抗物质 |
| ----------C07K16/28 | ..抗受体，细胞表面抗原或细胞表面决定因子 |