The invention discloses a device for imitating guide line corona under different temperature and different humidity. The device for imitating the guide line corona under the different temperature and the different humidity comprises an environmental climate laboratory, a temperature regulator, a humidity regulator, a guide line, a wall-through insulating sleeve and a high-voltage wire, wherein the temperature regulator and the humidity regulator are arranged in the environmental climate laboratory, the guide line is arranged between two side walls of the environmental climate laboratory, a through hole is formed in the environmental climate laboratory, the wall-through insulating sleeve is arranged in the through hole, the high-voltage wire penetrates through the wall-through insulating sleeve and is connected with the guide line, the high-voltage wire is further connected with a high-voltage direct current and high-voltage alternating current generating device. According to the device for imitating the guide line corona under the different temperature and the different humidity, the environmental climate laboratory, the temperature regulator, the humidity regulator, the guide line and the high-voltage wire are arranged so as to achieve the purpose of being capable of imitating conditions of the guide line corona under the conditions of the different temperature, the different humidity and different icing thicknesses.