The invention relates to a composition for treating a hole or well, particularly a composite granular temperature-resistant salt-resistant chemical plugging agent. The composite granular temperature-resistant salt-resistant chemical plugging agent is prepared from a thermosetting resin, an inorganic reinforcer and a suspension agent in a mass ratio of (10-12):(8-10):(0.2-0.4). The preparation method of a composite granular temperature-resistant salt-resistant chemical plugging agent colloid comprises the following steps: dissolving the composite granular temperature-resistant salt-resistant chemical plugging agent specified in Claim 1 in tap water, filling in a stainless steel cylinder, sealing, and treating in a 140 DEG C drying oven at constant temperature for 5.5 hours. The invention has the advantages of simple components, low cost and high strength, and is convenient for preparation and simple for construction. The test proves that the composite granular temperature-resistant salt-resistant chemical plugging agent has the advantages of high plugging rate, high plugging strength, scour resistance, high long-term stability and favorable salt resistance.