基本信息:
- 专利标题： 2-取代苯炔基-1,2-二氢-1-萘醇化合物及其制备方法与在制备抗乙酰胆碱酯酶药物中的应用
- 专利标题（英）：2-substituted benzene alkynyl-1,2-dihydro-1-naphthalene alcohol compound, preparation method thereof and application of compound to preparation of acetylcholinesterase resisting medicine
- 申请号：CN201210344317.8 申请日：2012-09-17
- 公开(公告)号：CN102875336A 公开(公告)日：2013-01-16
- 发明人： 龙玉华 , 邹致富 , 陈凯旋 , 姜晗
- 申请人： 华南师范大学
- 申请人地址： 广东省广州市天河区中山大道西55号
- 专利权人： 华南师范大学
- 当前专利权人： 华南师范大学
- 当前专利权人地址： 广东省广州市天河区中山大道西55号
- 代理机构： 广州市深研专利事务所
- 代理人： 姜若天
- 主分类号： C07C35/52
- IPC分类号： C07C35/52 ; C07C35/36 ; C07C29/64 ; C07C43/23 ; C07C41/30 ; C07C205/18 ; C07C201/12 ; A61K31/045 ; A61K31/085 ; A61P25/28
The invention discloses 2-substituted benzene alkynyl-1,2-dihydro-1-naphthalene alcohol compound, a preparation method thereof and application of the compound to preparation of acetylcholinesterase resisting medicines. The2-substituted benzene alkynyl-1,2-dihydro-1-naphthalene alcohol compound has a structural formula shown as a formula (I), R1, R2 and R3 are respectively selected from -H, -C1, -Br, -NO2, -CH3, -CH2CH3, -CH2CH2CH3, -(CH2)4CH3 or -OCH3. The preparation route of the 2-substituted benzene alkynyl-1,2-dihydro-1-naphthalene alcohol is simple, and the 2-substituted benzene alkynyl-1,2-dihydro-1-naphthalene alcohol is low in cost, small in environmental pollution and suitable for large-scale industrial production. The 2-substituted benzene alkynyl-1,2-dihydro-1-naphthalene alcohol has high inhibitory activity on acetylcholinesterase and has a wide application prospect in preparing the acetylcholinesterase resisting medicines.
公开/授权文献:
- CN102875336B 2-取代苯炔基-1,2-二氢-1-萘醇化合物及其制备方法与在制备抗乙酰胆碱酯酶药物中的应用 公开/授权日：2014-03-26