The invention provides a novel B type large-pore volume silica gel and a manufacture method of the novel B type large-pore volume silica gel. The manufacture method comprises the following steps of A, generating orthosilicic acid in a vortex type mixing reactor through sodium silicate solution and diluted mineral acid according to the conventional silica gel technology, and then standing and curing, and granulating twice; B, heating and curing, transferring the silica gel in an environment at 40 to 90 DEG C for being retained for 8 to 24 hours; C, surfacing the washed silica gel through inorganic salt and inorganic base, wherein for modifying the internal silanol on the internal surface of the silica gel hole, the alkaline can be sodium hydroxide, potassium hydroxide and lithium hydrate; and the inorganic salt can be ammonium chloride, sodium chloride, sodium carbonate, sodium bicarbonate and ammonium bicarbonate; and D, reinforcing the framework through the technology of dipping mineral acid and inorganic salt and thermally processing. According to the manufacture method, the silica gel is transferred into 0.01 to 10% of inorganic salt solution for being heated in water bath, and then is parched in a thermal environment at 100 to 200 DEG C, thus obtaining the silica gel provided by the invention. The manufacture method provided by the invention is simple, and easy to achieve mass production.