基本信息:
- 专利标题： 结合分子
- 专利标题（英）：Binding molecules
- 申请号：CN201210057684.X 申请日：2005-07-22
- 公开(公告)号：CN102659941A 公开(公告)日：2012-09-12
- 发明人： 罗杰·金登·克雷格 , F·G·格洛斯费尔德 , R·W·杨森斯 , D·德拉贝克
- 申请人： 伊拉兹马斯大学鹿特丹医学中心 , 罗杰·金登·克雷格
- 申请人地址： 荷兰鹿特丹
- 专利权人： 伊拉兹马斯大学鹿特丹医学中心,罗杰·金登·克雷格
- 当前专利权人： 伊拉兹马斯大学鹿特丹医学中心,罗杰·金登·克雷格
- 当前专利权人地址： 荷兰鹿特丹
- 代理机构： 中国专利代理(香港)有限公司
- 代理人： 孔青; 郭文洁
- 优先权： 0416392.9 20040722 GB; 0511881.5 20050610 GB
- 分案原申请号： 2005800315299 2005.07.22
- 主分类号： C07K16/00
- IPC分类号： C07K16/00 ; C12N15/13 ; C12N15/63 ; C12N1/15 ; C12N1/19 ; C12N1/21 ; C12N5/10 ; C12P21/00 ; A61K39/395 ; A61P37/02 ; G01N33/53
Binding molecules. The present invention relates to the manufacture of a diverse repertoire of functional heavy chain-only antibodies that undergo affinity maturation, and uses thereof. The invention also relates to the manufacture and use of a diverse repertoire of class-specific heavy chain-only antibodies and to the manufacture and use of multivalent polypeptide complexes with antibody heavy chain functionality, preferably antibody heavy chain binding functionality, constant region effector activity and, optionally, additional effector functions. The present invention also relates to a method of generation of fully functional heavy chain-only antibodies in transgenic mice in response to antigen challenge. In particular, the present invention relates to a method for the generation of human antigen-specific, high affinity, heavy chain-only antibodies of any class, or mixture of classes and the isolation and expression of fully functional VH antigen-binding domains.
公开/授权文献:
- CN102659941B 结合分子 公开/授权日：2016-01-20