The invention discloses an airlift sonochemical reactor, which is characterized in that: a vertical reacting cylinder is arranged; an ozone distributor with a gas outlet being upwards is arranged on the bottom of the reacting cylinder, a water outlet of a waste liquid tubing guide is close to the upper of the distributor, and keeps flow direction of water outlet being symmetrical with flow direction of ozone; energy transducers are arranged on the internal side wall of the reacting cylinder in an array manner, and a low frequency energy transducer and a high frequency energy transducer in a same horizontal plane are oppositely arranged on a same diameter line to form a energy transducer pair; and the number of the energy transducer pairs on a same horizontal plane is odd number, and the energy transducers uniformly distributed on a same circumference are arranged in an interval arrange manner of a low frequency energy transducer and a high frequency energy transducer. The airlift sonochemical reactor of the invention can high-efficiency utilize the synergism of ultrasonic wave and ozone, promotes acoustic cavitation effect, and can be used for treating industrial wastewater which is difficult to degrade.