基本信息:
- 专利标题： 口腔内崩解性包衣片剂
- 专利标题（英）：Orally disintegrating coated tablet
- 申请号：CN201080024902.9 申请日：2010-03-29
- 公开(公告)号：CN102448445A 公开(公告)日：2012-05-09
- 发明人： 高木卓 , 太田琴惠 , 堀内保秀
- 申请人： 东丽株式会社
- 申请人地址： 日本东京都
- 专利权人： 东丽株式会社
- 当前专利权人： 东丽株式会社
- 当前专利权人地址： 日本东京都
- 代理机构： 中国专利代理(香港)有限公司
- 代理人： 吴娟; 高旭轶
- 优先权： 2009-081916 2009.03.30 JP
- 国际申请： PCT/JP2010/055517 2010.03.29
- 国际公布： WO2010/113841 JA 2010.10.07
- 进入国家日期： 2011-11-30
- 主分类号： A61K9/36
- IPC分类号： A61K9/36 ; A61K31/133 ; A61K31/18 ; A61K31/426 ; A61K31/4422 ; A61K31/4439 ; A61K31/4515 ; A61K31/5517 ; A61K47/02 ; A61K47/10 ; A61K47/26 ; A61K47/32 ; A61K47/34 ; A61P1/04 ; A61P3/10 ; A61P13/08 ; A61P17/04 ; A61P25/20
Disclosed is a stable orally disintegrating coated tablet containing a medicament, which is coated with a coating layer that contains a water-soluble substance and not less than 5% by weight of a polyvinyl alcohol resin relative to the weight of the coating layer. The water-soluble substance is dissolved in less than 10 mL of water in an amount of 1g or more at 20 DEG C, has a hydroxy group in each molecule, and has a molecular weight of 200 or less per unit hydroxy group. The orally disintegrating coated tablet assures rapid disintegration in the oral cavity, while being stable since no cracks occur in the coating layer even when the orally disintegrating coated tablet has swollen by moisture absorption under high humidity conditions. In addition, when a medicament that is unstable with respect to light is contained in the orally disintegrating coated tablet, decomposition of the medicament can be suppressed by blending a light shielding agent in the coating layer.
公开/授权文献:
- CN102448445B 口腔内崩解性包衣片剂 公开/授权日：2014-03-05
IPC结构图谱:
| A | 人类生活必需 |
| --A61 | 医学或兽医学；卫生学 |
| ----A61K | 医用、牙科用或梳妆用的配制品 |
| ------A61K9/00 | 以特殊物理形状为特征的医药配制品 |
| --------A61K9/10 | .分散液；乳剂 |
| ----------A61K9/22 | ..持续释放或间断释放型 |
| ------------A61K9/30 | ...有机包衣层 |
| --------------A61K9/36 | ....含碳水化合物或其衍生物的 |