The invention provides an all-terrain guide rail type running mechanism, mainly composed of an actuating mechanism, running wheels, circular guide rails and a support frame, wherein the running wheels are connected with the driving shaft of the actuating mechanism; each running wheel is correspondingly provided with one circular guide rail; the running wheels are arranged in the corresponding circular guide rails; cog belts are fixedly arranged on the inner side surfaces of the circular guide rails; gear teeth meshed with the cog belts 5 on the circular guide rails are arranged on the running wheels; grooves along the circumferential direction are also arranged on the end faces of the circular guide rails; one end of the support frame is sleeved on the driving shaft through a bearing I; the other end of the support frame is fixedly connected with a support shaft vertical to the support frame; and the support shaft is arranged in the grooves on the end faces of the circular guide rails through a bearing II. The running mechanism has a simple structure, can easily climb over ditches and ground cracks, has a strong obstacle crossing capability and improves the transport efficiency.