基本信息:
- 专利标题： 一种泰利霉素关键中间体5-德胺糖基-6-O-甲基红霉素的合成方法
- 专利标题（英）：Method for synthesizing telithromycin key intermediate 5-deoaminyl-6-O-methylerythromycin
- 申请号：CN201110429285.7 申请日：2011-12-20
- 公开(公告)号：CN102417532A 公开(公告)日：2012-04-18
- 发明人： 邱家军 , 侯仲轲 , 王金龙 , 金勇 , 周志奎 , 吴青华 , 王霞
- 申请人： 浙江国邦药业有限公司
- 申请人地址： 浙江省绍兴市上虞市杭州湾上虞工业园区纬五路6号
- 专利权人： 浙江国邦药业有限公司
- 当前专利权人： 浙江国邦药业有限公司
- 当前专利权人地址： 浙江省绍兴市上虞市杭州湾上虞工业园区纬五路6号
- 代理机构： 绍兴市越兴专利事务所
- 代理人： 蒋卫东
- 主分类号： C07H17/08
- IPC分类号： C07H17/08 ; C07H1/00
The invention provides a method for synthesizing a telithromycin key intermediate 5-deoaminyl-6-O-methylerythromycin. The method comprises the following steps of: adding a precursor, namely an oxime protected object of clarithromycin into a solvent, adding a certain amount of acid, and removing cladinose at a certain temperature; maintaining a certain pH value and certain temperature, dripping a deoximation agent and acid, and controlling the pH value and maintaining for certain time; and finally, regulating the pH value by using alkali to obtain the 5-deoaminyl-6-O-methylerythromycin. In the process, the pH values during acidolysis and deoximation are controlled respectively, and the acidolysis and deoximation are continuously finished; the process is simple, the yield and the purity are high, and the cost is low; and the precursor of the clarithromycin is taken as a raw material, and the intermediate and the clarithromycin can be coproduced, so the method has industrialized prospect.
IPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07H | 糖类；及其衍生物；核苷；核苷酸；核酸 |
| ------C07H17/00 | 含有直接连在糖化物基团的杂原子上的杂环基的化合物 |
| --------C07H17/04 | .仅含有氧作为杂环原子的杂环基 |
| ----------C07H17/08 | ..含有八元或更多元的杂环，如红霉素 |