基本信息:
- 专利标题： 无污、抗菌、抗血栓形成的接出型接枝复合体
- 专利标题（英）：Non-fouling, anti-microbial, anti-thrombogenic graft-from compositions
- 申请号：CN200980156107.2 申请日：2009-12-07
- 公开(公告)号：CN102307955A 公开(公告)日：2012-01-04
- 发明人： 李军 , T·斯奎尔 , Z·张 , W·S·奥肖内西 , M·亨克 , M·布沙尔德 , C·R·洛斯 , C·胡瓦尔
- 申请人： 森普鲁斯生物科学公司
- 申请人地址： 美国马萨诸塞州
- 专利权人： 森普鲁斯生物科学公司
- 当前专利权人： 弓箭国际公司
- 当前专利权人地址： 美国马萨诸塞州
- 代理机构： 北京市中咨律师事务所
- 代理人： 黄革生; 林柏楠
- 优先权： 61/120,312 2008.12.05 US; 61/120,292 2008.12.05 US; 61/120,285 2008.12.05 US; 61/231,346 2009.08.05 US
- 国际申请： PCT/US2009/067013 2009.12.07
- 国际公布： WO2010/065960 EN 2010.06.10
- 进入国家日期： 2011-08-04
- 主分类号： C09D5/16
- IPC分类号： C09D5/16 ; A61L27/14 ; C08F4/40 ; C09D151/00
Substrates, optionally coated with an undercoating layer, having grafted there from one or more non-fouling materials are described herein. The non-fouling, polymeric material can be grafted from a variety of substrate materials, particularly polymeric substrates and/or polymeric undercoating layers. The graft-from techniques described herein can result in higher surface densities of the non-fouling material relative to graft-to formulations. Graft-from methods can be used to produce covalently tethered polymers. The compositions described herein are highly resistant protein absorption, particularly in complex media and retain a high degree of non-fouling activity over long periods of time. The compositions described herein may also demonstrate antimicrobial and/or anti-thrombogenic activity. The non-fouling material can be grafted from the substrate, or optionally from an undercoating layer on the substrate, preferably without significantly affecting the mechanical and/or physical properties of the substrate material.
公开/授权文献:
- CN102307955B 无污、抗菌、抗血栓形成的接出型接枝复合体 公开/授权日：2014-09-10